Identification of estrogen receptor proteins in breast cancer cells using matrix-assisted laser desorption/ionization time of flight mass spectrometry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872947" target="_blank" >RIV/62157124:16270/14:43872947 - isvavai.cz</a>

Alternative codes found

RIV/62156489:43210/14:43907785

Result on the web

<a href="http://dx.doi.org/10.3892/ol.2014.1912" target="_blank" >http://dx.doi.org/10.3892/ol.2014.1912</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ol.2014.1912" target="_blank" >10.3892/ol.2014.1912</a>

Result language

angličtina

Original language name

Identification of estrogen receptor proteins in breast cancer cells using matrix-assisted laser desorption/ionization time of flight mass spectrometry

Original language description

Estrogen receptors [ERs (subtypes alfa and beta)], clas?sified as a nuclear receptor super family, are intracellular proteins with an important biological role as the transcription factors for estrogen target genes. For ER induced transcription, an interaction must exist between ligand and coregulators. Coregulators may stimulate (coactivators) or inhibit (corepres?sors) transcription, following binding with a specific region of the gene, called the estrogen response element. Misbalanced activity of coregulators or higher ligand concentrations may cause increased cell proliferation, resulting in specific types of cancer. These are exhibited as overexpression of ER proteins. Breast cancer currently ranks first in the incidence and second in the mortality of cancer in females worldwide. In addition, 70% of breast tumors are ERalfa positive and the importance of these proteins for diagnostic use is indisputable. Early diagnosis of the tumor and its classification has a large influ?ence on

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology letters

ISSN

1792-1074

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

4

Pages from-to

1341-1344

UT code for WoS article

000337558000003

EID of the result in the Scopus database

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