Hybrid Hydrogel Networks by Photocrosslinking of Thermoresponsive alpha,omega-Itaconyl-PLGA-PEG-PLGA Micelles in Water: Influence of the Lithium Phenyl-2,4,6-Trimethylbenzoylphosphinate Photoinitinator
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F20%3APU137209" target="_blank" >RIV/00216305:26620/20:PU137209 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202000165" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202000165</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.202000165" target="_blank" >10.1002/macp.202000165</a>
Alternative languages
Result language
angličtina
Original language name
Hybrid Hydrogel Networks by Photocrosslinking of Thermoresponsive alpha,omega-Itaconyl-PLGA-PEG-PLGA Micelles in Water: Influence of the Lithium Phenyl-2,4,6-Trimethylbenzoylphosphinate Photoinitinator
Original language description
Modification of thermogelling biodegradable copolymers with functional groups enables further covalent crosslinking of physical micelle-based hydrogels formed at specific temperature in water. The resulting hybrid hydrogel network exhibits an increase in stiffness and degradation stability. In this work, synthesized well-defined thermoresponsive alpha,omega-itaconyl-poly(d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (alpha,omega-itaconyl-PLGA-PEG-PLGA) macromonomers with a high degree of itaconyl-substitution providing free double bonds are photocrosslinked in water at both 25 and 37 degrees C using lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LiTPO) acting as water-soluble non-toxic photoinitiator. The effect of LiTPO on the thixotropic behavior of macromonomer in water at 25 degrees C without irradiation is evaluated. With the addition of a low amount of the photoinitiator (0.1 wt%), the degree of copolymer thixotropy increases. However, further increase in the photoinitiator concentration (0.5-3 wt%) leads to a lower degree of thixotropy. The photoinitiator is presumably interfering with the micellar self-assembly of the copolymer. This trend is also reflected in photocrosslinking efficiency, where the hybrid hydrogel networks with the highest storage moduli are achieved with very low concentrations of the photoinitiator (0.1 wt%) at 25 degrees C, while this trend is reversed at 37 degrees C. The hydrolytic stability of hydrogels prepared at 37 degrees C from 17 wt% macromonomer solution with 1% LiTPO exceeds 22 days.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
1521-3935
Volume of the periodical
221
Issue of the periodical within the volume
17
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000557397900001
EID of the result in the Scopus database
2-s2.0-85089152376