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DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU140094" target="_blank" >RIV/00216305:26620/21:PU140094 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/21:00121537

  • Result on the web

    <a href="https://elifesciences.org/articles/60916#content" target="_blank" >https://elifesciences.org/articles/60916#content</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.7554/eLife.60916" target="_blank" >10.7554/eLife.60916</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

  • Original language description

    Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture of two tubular systems in 3D: double resin casting micro computed tomography (DUCT). As proof of principle, we applied DUCT to a mouse model for Alagille syndrome (Jag1Ndr/Ndr mice), characterized by intrahepatic bile duct paucity, that can spontaneously generate a biliary system in adulthood. DUCT identified increased central biliary branching and peripheral bile duct tortuosity as two compensatory processes occurring in distinct regions of Jag1Ndr/Ndr liver, leading to full reconstitution of wild-type biliary volume and phenotypic recovery. DUCT is thus a powerful new technology for 3D analysis, which can reveal novel phenotypes and provide a standardized method of defining liver architecture in mouse models.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10605 - Developmental biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    eLife

  • ISSN

    2050-084X

  • e-ISSN

  • Volume of the periodical

    neuveden

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    29

  • Pages from-to

    1-29

  • UT code for WoS article

    000625357100001

  • EID of the result in the Scopus database