Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU140632" target="_blank" >RIV/00216305:26620/21:PU140632 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/21:73609421
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0022328X21000693?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022328X21000693?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2021.121748" target="_blank" >10.1016/j.jorganchem.2021.121748</a>

Result language
angličtina
Original language name
Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity
Original language description
Three dinuclear half-sandwich iridium(III) complexes [Ir-2(mu-L1)(eta(5)-Cp*)(2)Cl-2](PF6)2 (1), [Ir-2(mu-L2)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (2) and [Ir-2(mu-L3)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3) with tetradentate 4,4'-methylenedianiline-based N-donor ligands (L1-L3) were prepared and characterized by NMR spectroscopy, elemental analysis, mass spectrometry and FTIR spectroscopy. Complex 3 was hydrolytically less stable in 20% DMSO-d(6)/80% D2O than 1 and 2, while all the studied complexes were stable in the same mixture of solvents in the presence of PBS (pH 7.4). In addition, complexes 1-3 converted coenzyme NADH to its oxidized form (NAD(+)). Cytotoxicity of 1-3 was evaluated on five human cancer cell lines, in particular lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). The best-performing complex 2 showed comparable cytotoxicity to conventional cisplatin against the A549 and HepG2 cell lines. (C) 2021 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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