New Pt(II) diiodido complexes containing bidentate 1,3,4-thiadiazole-based ligands: Synthesis, characterization, cytotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73615121" target="_blank" >RIV/61989592:15310/22:73615121 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0020169322001037" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0020169322001037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2022.120891" target="_blank" >10.1016/j.ica.2022.120891</a>

Result language
angličtina
Original language name
New Pt(II) diiodido complexes containing bidentate 1,3,4-thiadiazole-based ligands: Synthesis, characterization, cytotoxicity
Original language description
Two diiodidoplatinum(II) complexes [PtI2(L1)1 (1) and [PtI2(L2)] (2) with isomeric bidentate 1,3,4-thiadiazole-based N-donor ligands (L1, L2) were prepared and characterized by multinuclear NMR spectroscopy, elemental analysis, infrared spectroscopy and mass spectrometry. Complexes 1 and 2 were hydrolytically stable in 50% DMF-d(7)/50% D2O and 50% DMF-d(7)/50% PBS in D2O (pH 7.4). Cytotoxicity of 1 and 2 was evaluated on five human cancer cell lines, i.e. lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). Only the HepG2 (IC50 = 22.0 and 17.8 mu M for 1 and 2, respectively) and A549 (IC50 = 18.5 mu M for 1) cells were sensitive to the studied complexes, but their in vitro cytotoxicity was slightly lower than determined for the reference drug cisplatin (IC50 = 12.0 and 12.3 mu M at the HepG2 and A549 cells, respectively). Both complexes 1 and 2 effectively quenched the fluorescence of the EtBr-DNA system (EtBr = ethidium bromide) but did not interact covalently with guanosine monophosphate used as a model DNA molecule.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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