Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F21%3A73609421" target="_blank" >RIV/61989592:15310/21:73609421 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/21:PU140632

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0022328X21000693" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022328X21000693</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jorganchem.2021.121748" target="_blank" >10.1016/j.jorganchem.2021.121748</a>

Result language

angličtina

Original language name

Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Original language description

Three dinuclear half-sandwich iridium(III) complexes [Ir-2(mu-L1)(eta(5)-Cp*)(2)Cl-2](PF6)2 (1), [Ir-2(mu-L2)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (2) and [Ir-2(mu-L3)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3) with tetradentate 4,4&apos;-methylenedianiline-based N-donor ligands (L1-L3) were prepared and characterized by NMR spectroscopy, elemental analysis, mass spectrometry and FTIR spectroscopy. Complex 3 was hydrolytically less stable in 20% DMSO-d(6)/80% D2O than 1 and 2, while all the studied complexes were stable in the same mixture of solvents in the presence of PBS (pH 7.4). In addition, complexes 1-3 converted coenzyme NADH to its oxidized form (NAD(+)). Cytotoxicity of 1-3 was evaluated on five human cancer cell lines, in particular lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). The best-performing complex 2 showed comparable cytotoxicity to conventional cisplatin against the A549 and HepG2 cell lines.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF ORGANOMETALLIC CHEMISTRY

ISSN

0022-328X

e-ISSN

—

Volume of the periodical

938

Issue of the periodical within the volume

APR

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

"121748-1"-"121748-7"

UT code for WoS article

000632247300004

EID of the result in the Scopus database

2-s2.0-85101135170