Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142518" target="_blank" >RIV/00216305:26620/21:PU142518 - isvavai.cz</a>
Result on the web
<a href="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html" target="_blank" >https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis
Original language description
All surgeries carry the risk of complications due to bacterial infections. Infected hip or knee revisions are generally accompanied with local and systemic antibiotic therapy. Generally, in two-stage revisions, non- degradable poly(methyl methacrylate) spacers loaded with antibiotics are used. Only 3-5% of the antibiotic appears to be released during in vivo testing. To overcome this issue, we have developed a biodegradable, “self- setting”, thixotropic and osteoconductive bone cement based on polymer and calcium phosphate. In the presented work, we loaded the cement with either vancomycin or biogenic selenium nanoparticles (SeNPs) to compare their release and antimicrobial efficiency in vitro.
Czech name
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Czech description
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Project
<a href="/en/project/NV18-05-00379" target="_blank" >NV18-05-00379: Development and comprehensive evaluation of novel injectable, resorbable, porous bone substitute with controlled release of antimicrobial agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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