Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU147812" target="_blank" >RIV/00216305:26620/23:PU147812 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/23:00132629 RIV/62156489:43210/23:43921771 RIV/44555601:13440/23:43897160

Result on the web

<a href="https://doi.org/10.1016/j.bioactmat.2022.06.014" target="_blank" >https://doi.org/10.1016/j.bioactmat.2022.06.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bioactmat.2022.06.014" target="_blank" >10.1016/j.bioactmat.2022.06.014</a>

Result language

angličtina

Original language name

Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

Original language description

Although the general concept of nanotechnology relies on exploitation of size-dependent properties of nano -scaled materials, the relation between the size/morphology of nanoparticles with their biological activity re-mains not well understood. Therefore, we aimed at investigating the biological activity of Se nanoparticles, one of the most promising candidates of nanomaterials for biomedicine, possessing the same crystal structure, but differing in morphology (nanorods vs. spherical particles) and aspect ratios (AR, 11.5 vs. 22.3 vs. 1.0) in human cells and BALB/c mice. Herein, we report that in case of nanorod-shaped Se nanomaterials, AR is a critical factor describing their cytotoxicity and biocompatibility. However, spherical nanoparticles (AR 1.0) do not fit this statement and exhibit markedly higher cytotoxicity than lower-AR Se nanorods. Beside of cytotoxicity, we also show that morphology and size substantially affect the uptake and intracellular fate of Se nanomaterials. In line with in vitro data, in vivo i.v. administration of Se nanomaterials revealed the highest toxicity for higher-AR nanorods followed by spherical nanoparticles and lower-AR nanorods. Moreover, we revealed that Se nano -materials are able to alter intracellular redox homeostasis, and affect the acidic intracellular vesicles and cyto-skeletal architecture in a size-and morphology-dependent manner. Although the tested nanoparticles were produced from the similar sources, their behavior differs markedly, since each type is promising for several various application scenarios, and the presented testing protocol could serve as a concept standardizing the biological relevance of the size and morphology of the various types of nanomaterials and nanoparticles.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30108 - Toxicology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioactive Materials

ISSN

2452-199X

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

1

Country of publishing house

CN - CHINA

Number of pages

12

Pages from-to

489-500

UT code for WoS article

000830012200002

EID of the result in the Scopus database

2-s2.0-85133666485