Nano-TiO2 stability in medium and size as important factors of toxicity in macrophage-like cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00495266" target="_blank" >RIV/68378041:_____/19:00495266 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/19:00495266 RIV/00216208:11310/19:10405265 RIV/68407700:21230/19:00324113 RIV/61989100:27200/19:10242330
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0887233318306015?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0887233318306015?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tiv.2018.09.019" target="_blank" >10.1016/j.tiv.2018.09.019</a>
Alternative languages
Result language
angličtina
Original language name
Nano-TiO2 stability in medium and size as important factors of toxicity in macrophage-like cells
Original language description
TiO2 along with nano-TiO2 are commonly found in consumer products. In vivo studies have observed an accumulation of nano-TiO2 in macrophages. However, characteristics of nano-TiO2 determining toxicity remain unclear. In our study, the cytotoxic effects of 14 diverse nano-TiO2 on THP-1 macrophage-like cells were measured by 3 cytotoxicity assays (MTS, WST-1 and LDH). Total averaged cytotoxicity was calculated using principal component analysis. Characteristics of all 14 nano-TiO2 included hydrodynamic diameter, zeta potential, shape, polydispersity index (PDI) and concentration, moreover, crystal form, specific surface area and crystallite size were measured for 10 nano-TiO2. The variables affecting cytotoxicity were chosen using LASSO (least absolute shrinkage and selection operator). Except for concentration, PDI in media measured within 1 h after preparation of the nanomaterial dispersion was selected as a variable affecting cytotoxicity: stable dispersion resulted in higher cytotoxic effects. Crystallite size has been shown to have nonlinear effects (particles of sizes between 20 and 60 nm were cytotoxic while smaller and larger ones were not) and thus it has been excluded from LASSO. The shape (particles/fibre) and crystal form did not affect the cytotoxicity. PDI and the nonlinear effect of size could be an explanation for the inconsistencies of the cytotoxicity of nano-TiO2 in various studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology in Vitro
ISSN
0887-2333
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
feb.
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
178-188
UT code for WoS article
000454467300019
EID of the result in the Scopus database
2-s2.0-85054298234