Polydispersity Index in the Cell Medium and Crystalline Size Affect Toxicity of TiO2 Nanomaterial in THP-1 Cell Line

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00490620" target="_blank" >RIV/68378041:_____/17:00490620 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Polydispersity Index in the Cell Medium and Crystalline Size Affect Toxicity of TiO2 Nanomaterial in THP-1 Cell Line
Original language description
In this study, the cytotoxic effects of 14 diverse TiO2 NMs on THP-1 macrophage-like cells were measured by 3 viability assays. Variables affecting cytotoxicity were chosen using linear regression. Except concentration, polydispersity index (PDI) in media measured within 1 hour after preparation was selected as a variable affecting cytotoxicity: lower PDI, indicating stable dispersion, resulted in higher cytotoxic effects. Particles of size between 20-60 nm were cytotoxic while smaller and larger ones were not. Shape (particles/fibrous) and crystal form (anatase/rutile) did not show different cytotoxic effects. Overall, cytotoxicity of nano-TiO2 in THP-1 cells was low.
Czech name
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Czech description
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Project
<a href="/en/project/LO1508" target="_blank" >LO1508: Genomics and proteomics in the study of mechanisms of biological effects of produced nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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