Whole-genome Expression Analysis in THP-1 Macrophage-like Cells Exposed to Diverse Nanomaterials

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00490615" target="_blank" >RIV/68378050:_____/17:00490615 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/17:00490615
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Whole-genome Expression Analysis in THP-1 Macrophage-like Cells Exposed to Diverse Nanomaterials
Original language description
In the present study, we compared toxicity of four different types of NMs [NM-100 (TiO2, 110 nm), NM-110 (ZnO, 20 nm), NM-200 (SiO2, 150 nm) and NM-300K (Ag, 20 nm)] in THP-1 macrophage-like cells as a model cells of the first line of defense in the organism. Cells were incubated with non-cytotoxic concentrations (1-25 µg/ml) of NMs for 24 hours and microarray technology was used to analyze changes in whole-genome expression. NM-100 did not exert any significant effect, all other NMs triggered a pro-inflammatory response and induced expression of numerous chemokines and cytokines. NM-110 and NM-300K further modulated processes such as DNA damage response, oxidative stress as well as cell cycle progression and proteasome function.
Czech name
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Czech description
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Project
<a href="/en/project/LO1508" target="_blank" >LO1508: Genomics and proteomics in the study of mechanisms of biological effects of produced nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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