MWCNTs-supported Ni electrocatalyst-modified CPE as a sensing platform for voltammetric determination of ibuprofen in pharmaceutical formulations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU151583" target="_blank" >RIV/00216305:26620/24:PU151583 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/24:43924884
Result on the web
<a href="https://link.springer.com/article/10.1007/s00706-023-03158-0" target="_blank" >https://link.springer.com/article/10.1007/s00706-023-03158-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-023-03158-0" target="_blank" >10.1007/s00706-023-03158-0</a>
Alternative languages
Result language
angličtina
Original language name
MWCNTs-supported Ni electrocatalyst-modified CPE as a sensing platform for voltammetric determination of ibuprofen in pharmaceutical formulations
Original language description
In this work, a sensitive and reproducible voltammetric methodology using a modified carbon paste electrode has been established for the determination of the non-steroidal anti-inflammatory drug ibuprofen. MWCNTs-supported Ni electrocatalyst was applied as a bulk carbon paste modifier to fabricate the Ni-MWCNTs-CPE sensor, while square-wave voltammetry was utilized as an electroanalytical technique. Besides, cyclic voltammetry was used to study the electrochemical behavior of ibuprofen on the proposed sensor. Parameters of square-wave voltammetry were optimized using acetate buffer pH 4.5 as an optimal electrolyte. In addition, the sensitivity of the modified carbon paste electrode, as a sensing element, was compared to the unmodified one. Under optimized conditions, a wide linear range was obtained with LOD and LOQ values of 0.86 and 2.61 mu M, and 0.13 and 0.39 mu M, for bare CPE and Ni-MWCNTs-CPE, respectively. The presence of the modifier in the paste improved the sensitivity of the carbon paste electrode by almost 7 times. In addition, the newly fabricated Ni-MWCNTs-CPE sensor showed better results in terms of precision (RSD up to 2.49%). Finally, the validated voltammetric methodology was successfully applied for the determination of ibuprofen content in pharmaceutical formulations, without any complicated preliminary preparation steps, with recovery values between 94.4 and 98.1%.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatshefte für Chemie
ISSN
0026-9247
e-ISSN
1434-4475
Volume of the periodical
155
Issue of the periodical within the volume
3-4
Country of publishing house
AT - AUSTRIA
Number of pages
9
Pages from-to
289-297
UT code for WoS article
001163646800001
EID of the result in the Scopus database
2-s2.0-85185116427