Improving the processability and mechanical strength of self-hardening robocasted hydroxyapatite scaffolds with silane coupling agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F25%3APU154925" target="_blank" >RIV/00216305:26620/25:PU154925 - isvavai.cz</a>
Result on the web
<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:001359363900001" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:001359363900001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmbbm.2024.106792" target="_blank" >10.1016/j.jmbbm.2024.106792</a>
Alternative languages
Result language
angličtina
Original language name
Improving the processability and mechanical strength of self-hardening robocasted hydroxyapatite scaffolds with silane coupling agents
Original language description
Bone cements are the subject of intensive research, primarily due to their versatility and the increasing importance for personalized medicine. In this study, novel hybrid self-setting scaffolds, based on calcium phosphates and natural polymers, were fabricated using the robocasting technique. Additionally, the influence of two different silane coupling agents, tetraethyl orthosilicate (TEOS) and 3-glycidoxypropyltrimethoxysilane (GPTMS), on the physicochemical and biological properties of the obtained materials was thoroughly investigated. The chemical and phase compositions (XRF, XRD, FTIR), setting process, rheological properties, mechanical strength, microstructure (SEM), and chemical stability in vitro were comprehensively examined. The use of silane coupling agents improved compressive strength of the scaffolds from 5.20 to 9.26 MPa. The incorporation of citrus pectin into the liquid phase of the materials, along with the use of a hybrid hydroxyapatitechitosan powder, not only facilitated the development of printable pastes suitable for robocasting but also enhanced the physicochemical properties of the robocasted scaffolds. The results presented in this study underscore the beneficial influence of silane coupling agents on the characteristics of calcium phosphate-based bone scaffolds. Developed robocasted scaffolds hold great potential for applications in the field of bone tissue engineering and personalized medicine. Further in vitro and in vivo studies are necessary to validate their suitability for clinical applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20600 - Medical engineering
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the mechanical behavior of biomedical materials
ISSN
1751-6161
e-ISSN
1878-0180
Volume of the periodical
161
Issue of the periodical within the volume
106792
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
„“-„“
UT code for WoS article
001359363900001
EID of the result in the Scopus database
2-s2.0-85208933831