Microrobots for Antibiotic-Resistant Staphylococcus aureus Skin Colony Eradication

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0198756" target="_blank" >RIV/00216305:26620/26:0198756 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/25:43927260
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.5c08683" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.5c08683</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.5c08683" target="_blank" >10.1021/acsami.5c08683</a>

Result language
angličtina
Original language name
Microrobots for Antibiotic-Resistant Staphylococcus aureus Skin Colony Eradication
Original language description
Self-propelled nano- and micromachines have immense potential as autonomous seek-and-act devices in biomedical applications. In this study, we present microrobots constructed with inherently biocompatible materials and propulsion systems tailored to skin-related applications. Addressing the significant treatment challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) skin infections, we demonstrate that photocatalytic titanium dioxide microrobots decorated with silver or platinum can effectively and rapidly eradicate MRSA biofilms grown on skin-mimicking membranes and porcine skin tissues. These microrobots are powered by hydrogen peroxide or ultraviolet light-agents considered toxic in high concentrations but commonly used in controlled amounts for skin disinfection and naturally encountered by the skin. By examining the effects of different metal coatings on the propulsion abilities of the microrobots, we show that these chemically propelled devices can eliminate biofilms without causing significant damage to the surrounding skin tissues, as confirmed by histological analysis. This work paves the way for the use of microrobots in skin-related biomedical applications, particularly in cases where traditional antibiotics are ineffective.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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