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Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F17%3A10366036" target="_blank" >RIV/00669806:_____/17:10366036 - isvavai.cz</a>

  • Alternative codes found

    RIV/00843989:_____/17:E0106071 RIV/61988987:17110/17:A1901ZFY

  • Result on the web

    <a href="http://onlinelibrary.wiley.com/doi/10.1111/vox.12478/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/vox.12478/epdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/vox.12478" target="_blank" >10.1111/vox.12478</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population

  • Original language description

    Background and Objectives Alloimmune antibodies against red-blood-cell (RBC) antigens induced in susceptible individuals (responders) by transfusion, pregnancy or transplantation may have serious clinical consequences. The aim of this study was to investigate association of alloimmunization against selected RBC antigens with HLA-Class II. Materials and Methods A total of 230 responders (106 monoresponders and 124 multiresponders) were enrolled into the study. HLA-DRB1 and HLA-DQB1 variants were determined by PCR-SSO and their frequencies compared between the patients (patient subgroups) and 375 ethnically and regionally matched controls. Results Development of multiple RBC antibodies was associated with HLA-DRB1*15 and HLA-DQB1*06 allelic groups in the patients, with the relationship being particularly apparent in those with anti-C+D antibodies. Furthermore, DRB1*13 and DQB1*06 were more frequent in multiresponders with anti-E+c antibodies and DRB1*03 and DQB1*02 in those with anti-E+Cw. Conclusion For the first time, we confirmed the association of HLA-DRB1*15 with RBC antibody multiresponder status and found HLA-Class II associations for three frequent RBC antibody combinations. Our data support the concept that HLA restriction plays an important role in the response to RBC alloantigens.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Vox Sanguinis

  • ISSN

    0042-9007

  • e-ISSN

  • Volume of the periodical

    112

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    156-162

  • UT code for WoS article

    000396892300008

  • EID of the result in the Scopus database

    2-s2.0-85007545150