Association of multispecific red blood cell alloimmunization with HLA-Class II variants is related to Rh phenotypes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F21%3AE0108894" target="_blank" >RIV/00843989:_____/21:E0108894 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/21:73609647
Result on the web
<a href="http://www.elis.sk/download_file.php?product_id=7115&session_id=ntii2ei8eapgcvj57kj07t8341" target="_blank" >http://www.elis.sk/download_file.php?product_id=7115&session_id=ntii2ei8eapgcvj57kj07t8341</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2021_028" target="_blank" >10.4149/BLL_2021_028</a>

Result language
angličtina
Original language name
Association of multispecific red blood cell alloimmunization with HLA-Class II variants is related to Rh phenotypes
Original language description
Aim: It remains unclear, why only some patients form alloantibodies against foreign RBC antigens. Transfusion of red blood cell (RBC) products and pregnancy are the most relevant causes of immunization against RBC alloantigens. Here we investigated the relationship between RBC alloantibodies, Rh phenotype, and HLA phenotype among patients with multiple RBC alloantibodiesMETHODS: In a group of 124 multi-responders - including both pregnant women and transplant recipients - we analysed the distribution of HLA-Class II variants in subgroups of multi-responders to RBC alloantigens according to their Rh status. Results: As expected, the RhD-negative phenotype was overrepresented in our alloimmunized group (49.2 %) compared to in the general population. Importantly, HLA-DRB1*15 carriers were significantly overrepresented among D-negative multi-responders compared to D-positive multi-responders (Pc = 0.045). Furthermore, the linked HLA-DRB1*13, HLA-DQB1*06, and HLA-DQA1*01 variants were more frequent in individuals with the DCCee phenotype than in other RhD-positive phenotypes. Conclusion: Our present findings showed that RBC multispecific alloimmunization was associated with particular HLA-Class II variants based on Rh status (Tab. 3, Ref. 22).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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