Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1901ZFY" target="_blank" >RIV/61988987:17110/17:A1901ZFY - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/17:E0106071 RIV/00669806:_____/17:10366036
Result on the web
<a href="http://dx.doi.org/10.1111/vox.12478" target="_blank" >http://dx.doi.org/10.1111/vox.12478</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/vox.12478" target="_blank" >10.1111/vox.12478</a>
Alternative languages
Result language
angličtina
Original language name
Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population
Original language description
Alloimmune antibodies against red-blood-cell (RBC) antigens induced in susceptible individuals (responders) by transfusion, pregnancy or transplantation may have serious clinical consequences. The aim of this study was to investigate association of alloimmunization against selected RBC antigens with HLA-Class II. A total of 230 responders (106 monoresponders and 124 multiresponders) were enrolled into the study. HLA-DRB1 and HLA-DQB1 variants were determined by PCR-SSO and their frequencies compared between the patients (patient subgroups) and 375 ethnically and regionally matched controls. Development of multiple RBC antibodies was associated with HLA-DRB1*15 and HLA-DQB1*06 allelic groups in the patients, with the relationship being particularly apparent in those with anti-C+D antibodies. Furthermore, DRB1*13 and DQB1*06 were more frequent in multiresponders with anti-E+c antibodies and DRB1*03 and DQB1*02 in those with anti-E+Cw. For the first time, we confirmed the association of HLA-DRB1*15 with RBC antibody multiresponder status and found HLA-Class II associations for three frequent RBC antibody combinations. Our data support the concept that HLA restriction plays an important role in the response to RBC alloantigens.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
VOX SANG
ISSN
0042-9007
e-ISSN
1423-0410
Volume of the periodical
112
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
156-162
UT code for WoS article
000396892300008
EID of the result in the Scopus database
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