Single and multiple point NRAS mutations in acute myeloid leukemia: a study of 327 well molecularly characterized patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10448144" target="_blank" >RIV/00669806:_____/22:10448144 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/22:00013440 RIV/65269705:_____/22:00076249 RIV/00098892:_____/22:10157297 RIV/00179906:_____/22:10448144 RIV/00216224:14740/22:00126730
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p-FJQjhJ9u" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p-FJQjhJ9u</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10428194.2022.2116931" target="_blank" >10.1080/10428194.2022.2116931</a>

Result language
angličtina
Original language name
Single and multiple point NRAS mutations in acute myeloid leukemia: a study of 327 well molecularly characterized patients
Original language description
Oncogenic mutations in the NRAS gene are carried by 10-22% acute myeloid leukemia (AML) patients and represent one of the most commonly detected molecular aberrations in AML [1-6]. The mutations lead to increased activity of RAS pathway affecting cellular proliferation, survival, and differentiation [7]. NRAS mutations are mainly located in gene hotspots - codons 12, 13 (exon 2) and 61 (exon 3); mutations in other codons are detected rarely [1-5]. The hotspot mutations can be multiple and are often lost during disease progression [1,2,4,8,9]. Although NRAS alterations were first reported in AML more than 30 years ago, their prognostic impact as well as their contribution to malignant transformation remains disputed. The aim of this study was to determine the relevance of single and multiple point NRAS mutations in AML through detailed analysis of well molecularly characterized AML patients.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
<a href="/en/project/NV15-25809A" target="_blank" >NV15-25809A: National study of leukemia cell mutations and clonality in patients diagnosed with acute myeloid leukemia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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