Diagnostic accuracy of cystatin C and creatinine based estimation of glomerular filtration using various equations in pediatrics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F14%3AE0104494" target="_blank" >RIV/00843989:_____/14:E0104494 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Diagnostic accuracy of cystatin C and creatinine based estimation of glomerular filtration using various equations in pediatrics

Original language description

Introduction: The glomerular filtration rate (eGFR) is an important parameter for assessing renal function. The preferred methods for determining eGFR involve calculations using equations based on serum creatinine (Cr), cystatin C (CC) or a combination of these two biochemical markers without urine collection. Objectives: The aim of the study was to compare different equations to estimate GFR in children and to select the most optimal equation. Methods: We examined a group of 133 children from the Nephrology Outpatients of the Department of Paediatrics of University Hospital Ostrava. Serum samples were used to analyse Cr and CC. Statistical evaluation of results was performed using QC Expert and R software. Results: We examined six CC-based, four Cr-based and two Cr-and CC-based prediction equations. At the same time, all of the equations did not provide falsely high values of eGFR even at low values of CC. In the case of Cr-based eGFR equations, the CKD EPI equation correlated best with serum Cr and together with the Lund-Malmö equation did not provide falsely high values of eGFR. The correlation coefficients of CC- and Cr-based equations were comparable and CKD-EPI gave better results than the Zappitelli equation when assessing the resulting values of eGFR. The trueness of the equations for estimating eGFR values was assessed based on the median of all the equations. All medians of CC-based equations for eGFR were not significantly different with the exception of the KDIGO equation, which gave up to 23% lower values of bias. Of the Cr-based equations, the CKD-EPI equation provided up to 30% higher values of bias, while the Lund-Malmö equation provided much better results. The Schwartz and Counahan-Barratt equations provide at low concentrations of Cr comparable results with falsely positive values of eGFR. Conclusions: We conclude that the trueness of various CC-based equations provides comparable GFR levels as do combined CC- and Cr-based equations.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

CECE 2014. 11th International Interdisciplinary Meeting on Bioanalysis. October 20-22, 2014

ISBN

978-80-904959-2-0

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

"P. 306-309"

Publisher name

Institut of Analytical Chemistry ASCR

Place of publication

Brno

Event location

Brno, Czech Republic

Event date

Oct 20, 2014

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

000354547400099