The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F17%3AE0106711" target="_blank" >RIV/00843989:_____/17:E0106711 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/17:A1901ZFU
Result on the web
<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2016.11.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >10.1016/j.crvasa.2016.11.011</a>

Result language
angličtina
Original language name
The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease
Original language description
Aims: We sought to evaluate the influence of APOE polymorphisms (epsilon 2-rs7412, epsilon 4-rs429358) on plasma levels of apolipoprotein E in patients with confirmed coronary artery disease. Methods: A total of 94 patients with coronary artery disease were included in our study. Genotypisation for rs429358 and rs7412 in APOE was performed and plasma levels of apolipoprotein E, lipids, and hs-CRP were measured. Results: Significantly higher plasma levels of APOE were found in the epsilon 2 carriers compared to the normal epsilon 3/epsilon 3 genotype (40.4 mg/mL vs. 22.9 mg/mL, P = 0.018). There was no difference in APOE levels between the epsilon 4 allele and epsilon 3/epsilon 3 allele carriers. Significantly higher HDL cholesterol levels (1.55 mmol/L vs. 1.16 mmol/L, P = 0.001) were found in the epsilon 2 carriers, and significantly lower levels of hs-CRP (1.07 mg/L vs. 2.14 mg/L, P = 0.035) in the epsilon 4 carriers compared to the normal epsilon 3/epsilon 3 genotype. Conclusions: In CAD patients, the epsilon 2 APOE allele is associated with significantly higher plasma levels of APOE and HDL cholesterol, whereas the epsilon 4 allele is associated with significantly lower levels of hsCRP.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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