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The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1901ZFU" target="_blank" >RIV/61988987:17110/17:A1901ZFU - isvavai.cz</a>

  • Alternative codes found

    RIV/00843989:_____/17:E0106711

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2016.11.011</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >10.1016/j.crvasa.2016.11.011</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

  • Original language description

    We sought to evaluate the influence of APOE polymorphisms (epsilon 2-rs7412, epsilon 4-rs429358) on plasma levels of apolipoprotein E in patients with confirmed coronary artery disease. A total of 94 patients with coronary artery disease were included in our study. Genotypisation for rs429358 and rs7412 in APOE was performed and plasma levels of apolipoprotein E, lipids, and hs-CRP were measured. Significantly higher plasma levels of APOE were found in the epsilon 2 carriers compared to the normal epsilon 3/epsilon 3 genotype (40.4 mg/mL vs. 22.9 mg/mL, P = 0.018). There was no difference in APOE levels between the epsilon 4 allele and epsilon 3/epsilon 3 allele carriers. Significantly higher HDL cholesterol levels (1.55 mmol/L vs. 1.16 mmol/L, P = 0.001) were found in the epsilon 2 carriers, and significantly lower levels of hs-CRP (1.07 mg/L vs. 2.14 mg/L, P = 0.035) in the epsilon 4 carriers compared to the normal epsilon 3/epsilon 3 genotype. In CAD patients, the epsilon 2 APOE allele is associated with significantly higher plasma levels of APOE and HDL cholesterol, whereas the epsilon 4 allele is associated with significantly lower levels of hsCRP.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    COR ET VASA

  • ISSN

    0010-8650

  • e-ISSN

    1803-7712

  • Volume of the periodical

    59

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

    235-239

  • UT code for WoS article

    000410032200004

  • EID of the result in the Scopus database