The APOE ɛ2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73584930" target="_blank" >RIV/61989592:15110/17:73584930 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2016.11.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >10.1016/j.crvasa.2016.11.011</a>
Alternative languages
Result language
angličtina
Original language name
The APOE ɛ2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease
Original language description
Aims We sought to evaluate the influence of APOE polymorphisms (ɛ2-rs7412, ɛ4-rs429358) on plasma levels of apolipoprotein E in patients with confirmed coronary artery disease. Methods A total of 94 patients with coronary artery disease were included in our study. Genotypisation for rs429358 and rs7412 in APOE was performed and plasma levels of apolipoprotein E, lipids, and hs-CRP were measured. Results Significantly higher plasma levels of APOE were found in the ɛ2 carriers compared to the normal ɛ3/ɛ3 genotype (40.4 mg/mL vs. 22.9 mg/mL, P = 0.018). There was no difference in APOE levels between the ɛ4 allele and ɛ3/ɛ3 allele carriers. Significantly higher HDL cholesterol levels (1.55 mmol/L vs. 1.16 mmol/L, P = 0.001) were found in the ɛ2 carriers, and significantly lower levels of hs-CRP (1.07 mg/L vs. 2.14 mg/L, P = 0.035) in the ɛ4 carriers compared to the normal ɛ3/ɛ3 genotype. Conclusions In CAD patients, the ɛ2 APOE allele is associated with significantly higher plasma levels of APOE and HDL cholesterol, whereas the ɛ4 allele is associated with significantly lower levels of hsCRP.
Czech name
—
Czech description
—
Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cor et Vasa
ISSN
0010-8650
e-ISSN
—
Volume of the periodical
59
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
"E235"-"E239"
UT code for WoS article
000410032200004
EID of the result in the Scopus database
2-s2.0-85008487957