Fatal intoxication by intravenous injection of castor bean (Ricinus communis L.) extract - a case study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F20%3AE0108629" target="_blank" >RIV/00843989:_____/20:E0108629 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs00414-020-02340-x" target="_blank" >https://link.springer.com/article/10.1007%2Fs00414-020-02340-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00414-020-02340-x" target="_blank" >10.1007/s00414-020-02340-x</a>

Result language

angličtina

Original language name

Fatal intoxication by intravenous injection of castor bean (Ricinus communis L.) extract - a case study

Original language description

A case report of a 25-year-old man who committed suicide by intravenous injection himself of an aqueous home-made castor bean extract is presented. The patient was hospitalized and treated symptomatically and was released at its own request fourth day after intoxication. The next day, the patient’s condition deteriorated, and he died 6 days after intoxication even though he was given medical care. Case history, autopsy, and toxicological investigation of ante- and post-mortem collected materials are described. Blood and urine collected from the patient ante-mortem and other several biological materials (namely blood from the upper and lower limb, blood from the right and left ventricle, pericardial fluid, vitreous humour, liver, kidney, and spleen) were collected post-mortem during autopsy. Liquid–liquid extraction procedure followed by high-performance liquid chromatography tandem mass spectrometry analysis for identification and determination of ricinine as a biomarker of ricin/castor seed intoxication was developed and validated. The method was applied on analysis of collected ante- and post-mortem biological materials. The post-mortem contents of ricinine in organs (namely the liver, kidney, and spleen) are firstly reported. The obtained results indicated approximately uniform distribution of ricinine (concentration level about 1 ng mL-1) in the body after death. In addition, the GC-MS method was also applied for the analysis of extract of castor seed and the patient’s urine, to demonstrate alternative possibility for identification of ricinine for clinical and forensic purposes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30501 - Forensic science

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of legal medicine

ISSN

0937-9827

e-ISSN

1437-1596

Volume of the periodical

134

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

2133-2141

UT code for WoS article

000540689600002

EID of the result in the Scopus database

2-s2.0-85093478109