Preoperative tumour size assessment in patients with early-stage cervical cancer: Final results of the SENTIX study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111632" target="_blank" >RIV/00843989:_____/25:E0111632 - isvavai.cz</a>
Alternative codes found
RIV/27661989:_____/25:10002998 RIV/61988987:17110/25:A2603DO2 RIV/00216208:11110/25:10498438 RIV/00064165:_____/25:10498438
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0090825825001635?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0090825825001635?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygyno.2025.04.005" target="_blank" >10.1016/j.ygyno.2025.04.005</a>
Alternative languages
Result language
angličtina
Original language name
Preoperative tumour size assessment in patients with early-stage cervical cancer: Final results of the SENTIX study
Original language description
Background: Preoperative tumour size is a key prognostic marker in tailoring surgical treatment in early-stage cervical cancer. This post-hoc analysis assessed the accuracy of preoperative tumour size evaluation via imaging, utilizing data from the prospective, international, multicentre SENTIX study that evaluated safety of sentinel lymph node (SLN) biopsy without pelvic lymph node dissection in patients with early-stage cervical cancer. Methods: Between 05/2016-09/2020, forty-seven sites across 18 countries enrolled cervical cancer patients (FIGO2018 stages 1A1/lymphovascular-space-invasion-positive to 1B2). Preoperative staging included pelvic MRI or ultrasound as mandatory imaging modalities. All patients underwent primary surgical treatment. Pathological assessment of surgical specimens served as reference standard for evaluating the accuracy of preoperative assessments. Results: Among the 680 included patients, although the mean tumour size discrepancy between preoperative/pathological assessments was only 1.24 ± 8.891 mm, postoperative pT stage was upgraded in 187 (27.5 %) and downgraded in 74 (10.9 %) patients. Discrepancy of ?10 mm was observed among 155 (22.8 %) patients across all stages, with underestimation in 105 (15.4 %), overestimation in 50 (7.4 %), and a positive correlation (P < 0.0001) between the pathological tumour size and the discrepancy in size assessment. If a maximum 2 cm tumour size threshold were applied to guide the decision between simple and radical hysterectomy, underestimation would result in inadequate surgical management for 9.0 % of patients, whereas overestimation would lead to unnecessarily radical procedures in 5.1 % of cases. Conclusions: The study highlights, that even with the use of modern imaging in preoperative staging, inaccuracies in tumour size assessment remain a common cause of up-/down-staging after surgery resulting in potential inappropriate planning of surgery, and thus in procedure that is either excessively...
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gynecologic oncology
ISSN
0090-8258
e-ISSN
1095-6859
Volume of the periodical
196
Issue of the periodical within the volume
may
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
160-167
UT code for WoS article
001476809700001
EID of the result in the Scopus database
2-s2.0-105002211360