Serum creatine kinase and transaminase levels in Duchenne and Becker muscular dystrophies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111864" target="_blank" >RIV/00843989:_____/25:E0111864 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143756 RIV/00216208:11130/25:10497814 RIV/65269705:_____/25:00082088 RIV/00064203:_____/25:10497814
Result on the web
<a href="https://doi.org/10.1002/mus.28431" target="_blank" >https://doi.org/10.1002/mus.28431</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mus.28431" target="_blank" >10.1002/mus.28431</a>
Alternative languages
Result language
angličtina
Original language name
Serum creatine kinase and transaminase levels in Duchenne and Becker muscular dystrophies
Original language description
Introduction/aims: The distinction between hepatic and muscular origin of transaminases in Duchenne (DMD) and Becker (BMD) muscular dystrophy is challenging. We aimed to describe the relations between creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT), and their evolution with age, the severity of the disease, and its complications (corticosteroid therapy, cardiac ejection fraction, body mass index [BMI]). Methods: Multiple regression analysis of the studied markers was performed in three cohorts: 1. Retrospective data of 212 DMD and BMD boys available in the national registry of muscular dystrophies (REaDY), and 2. Cross-sectional study supplemented by retrospective data of A. 64 DMD boys and B. 18 adults with either BMD or B/DMD carriers. Results: The estimation of normal levels of transaminases from CK levels was: ALT [UI/L] = 228.508 + 0.011*CK [UI/L] ± 341.822for DMD, and ALT [UI/L] = 124.498 + 0.011*CK [UI/L] ± 341.822for BMD. AST [UI/L] = 167.436 + 0.012*CK [UI/L]-6.323*Age ± 249.804 for both (all p < 0.001). In the smaller cohort, ALT was best predicted by LDH and physical performance, whereas AST was defined by CK and LDH combined (all p < 0.001). In DMD, all AST, ALT, CK, LDH, and myoglobin decreased with age (p < 0.001), while GGT increased with age and BMI (both p < 0.001). Discussion: Transaminases are dependent on CK and LDH in dystrophinopathy. There is an increase in GGT in DMD connected to BMI.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Muscle & nerve
ISSN
0148-639X
e-ISSN
1097-4598
Volume of the periodical
72
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
240-249
UT code for WoS article
001484937700001
EID of the result in the Scopus database
2-s2.0-105004778543