Effect of Diplacone on LPS-Induced Inflammmatory Gene Expression in Macrophages

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26249308%3A_____%2F10%3A%230000007" target="_blank" >RIV/26249308:_____/10:#0000007 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of Diplacone on LPS-Induced Inflammmatory Gene Expression in Macrophages
Original language description
This study focused on the ability of diplacone to modulate the gene expression of pro-inflammatory tumour necrosis factor alfa and monocyte chemoattractant protein 1, and of anti-inflammatory zinc finger protein 36. In model, diplacone significantly down-regulated the expression of tumour necrosis factor alfa and monocyte chemoattractant protein 1 and up-regulated the zinc finger protein 36 expression. This makes diplacone a promising molecule for treatment of the inflammatory stage of diseases. The effect of diplacone in decreasing lipopolysaccharide-induced inflammatory gene expression is in many way similar to that of the drug indomethacin.
Czech name
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Czech description
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Project
<a href="/en/project/FT-TA5%2F025" target="_blank" >FT-TA5/025: *Identification of probiotic lactic acid bacteria in probiotic pharmaceutical preparations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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