Blood coagulation and platelet adhesion on polyaniline films

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F15%3AN0000012" target="_blank" >RIV/27661989:_____/15:N0000012 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/15:00445122 RIV/70883521:28610/15:43873024 RIV/70883521:28150/15:43873024

Result on the web

<a href="https://www-sciencedirect-com.proxy.k.utb.cz/journal/colloids-and-surfaces-b-biointerfaces/vol/133/suppl/C" target="_blank" >https://www-sciencedirect-com.proxy.k.utb.cz/journal/colloids-and-surfaces-b-biointerfaces/vol/133/suppl/C</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfb.2015.06.008" target="_blank" >10.1016/j.colsurfb.2015.06.008</a>

Result language

angličtina

Original language name

Blood coagulation and platelet adhesion on polyaniline films

Original language description

Polyaniline is a promising conducting polymer with still increasing application potential in biomedicine. Its surface modification can be an efficient way how to introduce desired functional groups and to control its properties while keeping the bulk characteristics of the material unchanged. The purpose of the study was to synthetize thin films of pristine conducting polyaniline hydrochloride, non-conducting polyaniline base and polyaniline modified with poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPSA) and investigate chosen parameters of their hemocompatibility. The modification was performed either by introduction of PAMPSA during the synthesis or by reprotonation of polyaniline base. The polyaniline hydrochloride and polyaniline base had no impact on blood coagulation and platelet adhesion. By contrast, the polyaniline reprotonated with PAMPSA completely hindered coagulation thanks to its interaction with coagulation factors Xa, Va and IIa. The significantly lower platelets adhesion was also found on this surface. Moreover, this film maintains its conductivity at pH of 6, which is an improvement in comparison with standard polyaniline hydrochloride losing most of its conductivity at pH of 4. Polyaniline film with PAMPSA introduced during synthesis had an impact on platelet adhesion but not on coagulation. The combined conductivity, anticoagulation activity, low platelet adhesion and improved conductivity at pH closer to physiological, open up new possibilities for application of polyaniline reprotonated by PAMPSA in blood-contacting devices, such as catheters or blood vessel grafts. (C) 2015 Elsevier B.V. All rights reserved.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30400 - Medical biotechnology

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Colloids and Surfaces B-Biointerfaces

ISSN

0927-7765

e-ISSN

1873-4367

Volume of the periodical

133

Issue of the periodical within the volume

1 September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

278-285

UT code for WoS article

000359172600034

EID of the result in the Scopus database

2-s2.0-84935027104