A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46356088%3A_____%2F15%3A%230001713" target="_blank" >RIV/46356088:_____/15:#0001713 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26210/15:PU115691
Result on the web
<a href="http://dx.doi.org/10.1177/0954411915600005" target="_blank" >http://dx.doi.org/10.1177/0954411915600005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0954411915600005" target="_blank" >10.1177/0954411915600005</a>
Alternative languages
Result language
angličtina
Original language name
A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography
Original language description
Researchers have been studying aerosol transport in human lungs for some decades. The overall lung deposition can be predicted with sufficient precision nowadays. However, the prediction of local deposition remains an unsolved problem. Numerical modeling of aerosol transport can provide detailed data with such precision and spatial resolution which were unavailable in the past. Yet, the necessary validation of numerical results represents a difficult task, as the experimental data in a sufficient spatial resolution are hardly available. This article introduces a method based on positron emission tomography, which allows acquisition of detailed experimental data on local aerosol deposition in a realistic model of human lungs. The method utilizes the Condensation Monodisperse Aerosol Generator modified for a safe production of radioactive aerosol particles and a special measuring rig. The scanning of the model is performed on a positron emission tomography-computed tomography scanner. The evaluation of aerosol deposition is based on a volume radioactivity analysis in a specialized, yet publicly available software. The reliability of the method was tested and its first results are discussed in the article. The measurements performed using the presented method can serve for validation of numerical simulations, since the presented lung model digital geometry is available.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the institution of mechanical engineers part H - Journal of engineering in medicine
ISSN
0954-4119
e-ISSN
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Volume of the periodical
229
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
750-757
UT code for WoS article
000361899000007
EID of the result in the Scopus database
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