Evaluation of aerosol deposition in a realistic human airway model by PET/CT

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU130874" target="_blank" >RIV/00216305:26620/18:PU130874 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Evaluation of aerosol deposition in a realistic human airway model by PET/CT
Original language description
The investigation of the drug delivery into the lungs is essential for the effectiveness determination of their treatment. The numerical models are developed for the theoretical calculation of the particle deposition. The realistic human airway models were manufactured for the evaluation of the theoretical results. The overall drug accumulation is calculated but it is not possible to achieve the local deposition. The combined Positron Emission Tomography and X-ray Computed Tomography (PET/CT) imaging was applied for the local deposition analysis. The new algorithm for the precise identification of the individual section of the airway model in the CT data was created. PET/CT images were employed for the localization of deposited aerosol in the realistic model of the oral cavity and the following seven generation of the tracheobronchial tree. The realistic human airway model and the developed algorithm represent the new method for the precise local deposition of aerosol evaluation in human lungs.
Czech name
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Czech description
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Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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