Impact of Various Sterilization and Disinfection Techniques on Electrospun Poly-ε-caprolactone
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F20%3A00007529" target="_blank" >RIV/46747885:24210/20:00007529 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24410/20:00007529 RIV/46747885:24620/20:00007529
Result on the web
<a href="https://pubs.acs.org/doi/full/10.1021/acsomega.0c00503" target="_blank" >https://pubs.acs.org/doi/full/10.1021/acsomega.0c00503</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.0c00503" target="_blank" >10.1021/acsomega.0c00503</a>
Alternative languages
Result language
angličtina
Original language name
Impact of Various Sterilization and Disinfection Techniques on Electrospun Poly-ε-caprolactone
Original language description
Electrospun materials made from biodegradable polycaprolactone are used widely in various tissue engineering and regenerative medicine applications because of their morphological similarity to the extracellular matrix. However, the main prerequisite for the use of such materials in clinical practice consists of the selection of the appropriate sterilization technique. This study is devoted to the study of the impact of traditional sterilization and disinfection methods on a nanofibrous polycaprolactone layer constructed by means of the needleless electrospinning technique. It was determined that hydrogen peroxide plasma treatment led to the loss of fibrous morphology and the creation of a foil. However, certain sterilization (ethylene oxide, gamma irradiation, and peracetic acid) and disinfection techniques (ethanol and UV irradiation) were found not to lead to a change in morphology; thus, the study investigates their impact on thermal properties, molecular weight, and interactions with a fibroblast cell line. It was determined that the surface properties that guide cell adhesion and proliferation were affected more than the bulk properties. The highest proliferation rate of fibroblasts seeded on nanofibrous scaffolds was observed with respect to gamma-irradiated polycaprolactone, while the lowest proliferation rate was observed following ethylene oxide sterilization.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
<a href="/en/project/FV10416" target="_blank" >FV10416: Nanofibrous Wound Dressing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Omega
ISSN
2470-1343
e-ISSN
—
Volume of the periodical
5
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
8885-8892
UT code for WoS article
000527748400019
EID of the result in the Scopus database
2-s2.0-85083329838