Immobilization of enzymes on the silica nanofibers for burns treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00004059" target="_blank" >RIV/46747885:24410/16:00004059 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24530/16:00004059
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Immobilization of enzymes on the silica nanofibers for burns treatment
Original language description
For burns and necrotic wounds, removal of the necrotic tissue is the first step to successful treatment. Effective wound cleansing and debridement are essential for granulation and re-epithalisation. Now it is possible to replace a current very painful surgical removal with the enzymatic or autolytic debridement. Especially enzymatic debridement is a highly selective method that utilizes naturally occurring proteolytic enzymes. The reasons why the surgical removal has not yet been replaced by painless enzymatic debridement are low enzyme stability and many factors affecting enzymes activity (type of substrate, pH, temperature, etc.). The possibility to solve this problem is the enzyme immobilization on the suitable material - e.g. nanofibers with a lot of functional groups for covalent binding of the enzymes. As a supporting biocompatible and biodegradable material for immobilization of several enzymes types, the electrospun silica nanofibers were chosen. Proteolytic activity of immobilized enzymes was tested under different conditions.
Czech name
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Czech description
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application
ISBN
9788087294710
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
509-513
Publisher name
TANGER Ltd.
Place of publication
Ostrava
Event location
Brno
Event date
Jan 1, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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