Design of Polycaprolactone Vascular Grafts

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00008797" target="_blank" >RIV/46747885:24410/16:00008797 - isvavai.cz</a>
Result on the web
<a href="http://journals.sagepub.com/doi/pdf/10.1177/1528083714540701" target="_blank" >http://journals.sagepub.com/doi/pdf/10.1177/1528083714540701</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1528083714540701" target="_blank" >10.1177/1528083714540701</a>

Result language
angličtina
Original language name
Design of Polycaprolactone Vascular Grafts
Original language description
A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations in the replacement of small diameter vascular grafts, the need and demand for developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6 mm) vascular grafts were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved by increasing the rotational speed of the collector. The morphological, structural, mechanical, and biological properties were examined. The results show that oriented scaffolds with 2 µm average fiber diameter provide 1 MPa ultimate tensile strength in the radial direction. The pore size area was found to be adequate in the oriented samples required for cell proliferation and diffusion through the tunica media. In vitro biocompatibility of the grafts was proven with 3T3 mouse fibroblasts. After cell seeding, the oriented fibers serve as a cue for radial cell alignment. An understanding of electrospun material parameters together with knowledge of native blood vessel structures and properties is a considerable part in designing small-diameter vascular grafts.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20503 - Textiles; including synthetic dyes, colours, fibres (nanoscale materials to be 2.10; biomaterials to be 2.9)

Project
<a href="/en/project/GAP208%2F12%2F0105" target="_blank" >GAP208/12/0105: POLYMER SOLUTIONS IN AN EXTERNAL FIELD: MOLECULAR UNDERSTANDING OF ELECTROSPINNING</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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