Initial screening of silica nanofibres as drug delivery system for antibiotics in wound healing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F22%3A00011737" target="_blank" >RIV/46747885:24510/22:00011737 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24620/22:00011737

Result on the web

<a href="https://www.confer.cz/nanocon/2022/4611-initial-screening-of-silica-nanofibres-as-drug-delivery-system-for-antibiotics-in-wound-healing" target="_blank" >https://www.confer.cz/nanocon/2022/4611-initial-screening-of-silica-nanofibres-as-drug-delivery-system-for-antibiotics-in-wound-healing</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2022.4611" target="_blank" >10.37904/nanocon.2022.4611</a>

Result language

angličtina

Original language name

Initial screening of silica nanofibres as drug delivery system for antibiotics in wound healing

Original language description

Over the last decade, drug delivery systems for wound management have undergone a significant evolution as novel nano-based dosage forms and wound dressing pads for active wound management have been developed. Significance of these materials is based on the increasing demand for active wound dressing able to battle infection and inflammation in contaminated and slow-to-heal wounds. Nanofibres represent nanomaterials able to act simultaneously as wound dressing, protecting the wound, and drug delivery system for in situ drug release. Bioavailability of the drug and its release kinetics strongly depend on the drug‘s nature, nanofibrous matrix characteristics and mechanism of drug incorporation. In bacterial infection treatment, fast reaching of minimal inhibitory concentration (MIC) is crucial and can be achieved by mediated surface drug adsorption. In this work, we explored interactions of electrospun silica nanofibres with five model antibiotics from the tetracycline family in order to evaluate robustness of this novel nanofibrous drug delivery system. Drug-functionalized nanofibres were studied in terms of morphology and total drug content. Antibacterial activity against bacteria E. coli was tested in vitro. Overcoming the MIC value was achieved for all tested antibiotics. Biocompatibility was tested and confirmed on human dermal fibroblasts in vitro. Presence of all tested antibiotics led to increased cellular metabolic activity. Based on these results, we assumed that silica nanofibres represent a robust system able to bind and release variety of tetracycline antibiotics for contaminated wound management.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

30401 - Health-related biotechnology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

NANOCON 2022 - Conference Proceedings, 14th International Conference on Nanomaterials

ISBN

978-80-88365-09-9

ISSN

2694-930X

e-ISSN

—

Number of pages

6

Pages from-to

223-228

Publisher name

Tanger Ltd

Place of publication

Ostrava

Event location

Brno

Event date

Jan 1, 2022

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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