The effect of molecular weight of polycaprolactone in blend nanofibers on the vaginal microbiome response

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F25%3A00012798" target="_blank" >RIV/46747885:24510/25:00012798 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24620/25:00012798

Result on the web

<a href="https://www.confer.cz/nanocon/2024" target="_blank" >https://www.confer.cz/nanocon/2024</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effect of molecular weight of polycaprolactone in blend nanofibers on the vaginal microbiome response

Original language description

The health of the vaginal microbiota is a crucial component of an intricate system. Vaginal drug delivery systems play an integral role in women‘s health by offering targeted and efficient treatment options for various gynecological conditions, while aiming to minimally impact said bacterial population. We propose using nanofibrous materials based on the polymers polycaprolactone (PCL) and poly(lactic acid) (PLA) due to their favorable properties. The molecular weight of PCL can significantly influence the properties of blended nanofibers, which in turn affects their interaction with the vaginal microbiome. Higher molecular weight PCL tends to enhance the mechanical strength and stability of the nanofibers, potentially leading to a more controlled and sustained release of incorporated substances. This controlled release is crucial for maintaining a balanced microbiome, as it may help in the gradual release of antimicrobial agents or probiotics. A healthy vaginal microbiome is dominated by various types of Lactobacilli, which produce lactic acid and antimicrobial compounds. We tested the effect of blended nanofibers with PCL of two molecular weights (Mn 45,000 and 80,000) on the growth rate of three Lactobacilli species: L. crispatus, L. gasseri, and L. jensenii. There was no distinguishable effect on the growth rates of L. crispatus and L. gasseri, but the growth rate of L. jensenii was affected by PCL of both molecular weights. This is an important finding for future use of PCL based nanofibers in vaginal drug delivery.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

21001 - Nano-materials (production and properties)

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů