Primary Evaluation of Pcl/pei Nanofibres in Terms of the Surface Functionality for Biomolecules Attachment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F18%3A00007700" target="_blank" >RIV/46747885:24620/18:00007700 - isvavai.cz</a>
Result on the web
<a href="https://www.confer.cz/nanocon/2017/read/359-functional-nanofibres-for-biomedical-application-and-biomolecules-attachment.pdf" target="_blank" >https://www.confer.cz/nanocon/2017/read/359-functional-nanofibres-for-biomedical-application-and-biomolecules-attachment.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Primary Evaluation of Pcl/pei Nanofibres in Terms of the Surface Functionality for Biomolecules Attachment
Original language description
Paper in conference proseeding with abstract: Nanofibrous matrices represent an attractive material for biomedical applications - mainly due to their high specific surface and small pore size, which make them interesting material for drug delivery matrixes construction. Besides the morphological characteristics, the surface functionality strongly affects the drug-matrix interaction, drug conjugation and drug release kinetics. Implication of primary amino (-NH2) groups to the surface of nanofibres can improve their performance and enable conjugation of drug via covalent binding and/or electrostatic interactions. The aim of this study was to evaluate applicability a nanofibrous material based on blend of two biocompatible and biodegradable polymers -poly-epsilon-caprolactone (PCL) and polyethylenimine (PEI) produced by needleless electrospinning. The electrospun matrices were evaluated in terms of morphology, functional groups availability and short term stability. Moreover, biocompatibility to the 3T3 fibroblastic cell line was verified in direct contact. Binding capacity estimation was performed on a model molecule (BSA) in order to demonstrate binding capacity of the system and its applicability for protein immobilization for wound management.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
9th International Conference on Nanomaterials - Research and Application (NANOCON 2017)
ISBN
978-80-87294-81-9
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
605-610
Publisher name
Tanger
Place of publication
Brno
Event location
Brno
Event date
Jan 1, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000452823300100