Advanced Nanosystems for Cancer Therapeutics: A Review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F23%3A00012271" target="_blank" >RIV/46747885:24620/23:00012271 - isvavai.cz</a>

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acsanm.3c00859" target="_blank" >https://pubs.acs.org/doi/10.1021/acsanm.3c00859</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.3c00859" target="_blank" >10.1021/acsanm.3c00859</a>

Result language

angličtina

Original language name

Advanced Nanosystems for Cancer Therapeutics: A Review

Original language description

Since cancer has a very complex pathophysiology, existing cancer treatment strategies encounter several challenges such as the lack of specificity/selectivity, induction of multidrug resistance, and possible side effects/toxicity. A wide variety of organic, inorganic, and hybrid nanosystems have been designed with unique magnetic, thermal, mechanical, electrical, and optical properties for targeted cancer therapy. These advanced nanosystems with enhanced bioavailability, biocompatibility, and drug loading capacity have been developed for targeted cancer therapy to reduce toxicity and improve the targeting properties. In this context, challenges persist for their clinical translational studies and enhancement of their therapeutic efficiency as well as the optimization of synthesis conditions and large-scale production. In addition, despite promising preclinical results, the number of nanosystems available to patients is still very low, partly due to a lack of understanding of the differences among animal model species and humans that influence the behavior and functionality of these nanosystems. Regarding this, organ-on-a-chip platforms can significantly help in drug screening and delivery aspects in cancer/tumor cells as well as cancer modeling research; the organs-on-chip approach can also be helpful to analyze the cancer-immune cells interactions. Future studies should focus on the exploration of multifunctional nanosystems with synergistic chemo-photothermal, photothermal/photodynamic, and cancer immunotherapeutic potentials as well as smart nanosystems with theranostic capabilities. Herein, recent advancements pertaining to the applications of advanced nanosystems for cancer therapeutics are deliberated. Current obstacles and limitations hindering the application from research to clinical uses are also discussed while providing recommendations for a more efficient adoption of nanomaterials in the treatment of cancers.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

27

Pages from-to

7123 - 7149

UT code for WoS article

000980945800001

EID of the result in the Scopus database

2-s2.0-85156232965