Noninvasive assessment of carotid artery stenoses by the principle of multiscale modelling of non-Newtonian blood flow in patient-specific models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F18%3A43932402" target="_blank" >RIV/49777513:23520/18:43932402 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.amc.2017.07.032" target="_blank" >http://dx.doi.org/10.1016/j.amc.2017.07.032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.amc.2017.07.032" target="_blank" >10.1016/j.amc.2017.07.032</a>

Result language
angličtina
Original language name
Noninvasive assessment of carotid artery stenoses by the principle of multiscale modelling of non-Newtonian blood flow in patient-specific models
Original language description
The concept of geometrical multiscale modelling of non-Newtonian blood flow in patient-specific models is presented with the aim to provide a methodology for the assessment of hemodynamic significance of carotid artery stenoses. The content of the paper is divided into two consequent parts. In the first one, the principle of the fractional flow reserve (FFR) as an indicator of ischemia-inducing arterial stenoses is tested on three large arterial models containing the aortic arch and both left and right carotid arteries. Using the three-element Windkessel model as an outflow boundary condition, the blood flow simulations are carried out on the basis of data taken from the literature due to unavailable information on patient-specific flow and pressure waveforms. In the second part of the paper, the incorporation of real in-vivo measurements into the multiscale simulations is addressed by presenting a sequential algorithm for the estimation of Windkessel parameters. The ability of the described estimation method, which employs a non-linear state estimator (unscented Kalman filter) on zero-dimensional flow models, is demonstrated on two different patient-specific carotid bifurcation models.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10305 - Fluids and plasma physics (including surface physics)

Project
<a href="/en/project/LO1506" target="_blank" >LO1506: Sustainability support of the centre NTIS - New Technologies for the Information Society</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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