Programmable Hydrogels: Frontiers in Dynamic Closed-Loop Systems, Biomimetic Synergy, and Clinical Translation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F25%3A43977777" target="_blank" >RIV/49777513:23640/25:43977777 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/advs.202512037" target="_blank" >https://doi.org/10.1002/advs.202512037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/advs.202512037" target="_blank" >10.1002/advs.202512037</a>
Alternative languages
Result language
angličtina
Original language name
Programmable Hydrogels: Frontiers in Dynamic Closed-Loop Systems, Biomimetic Synergy, and Clinical Translation
Original language description
Programmable hydrogels are an emerging class of intelligent materials engineered to respond precisely to specific stimuli, offering tailored functionalities with significant potential for biomedical applications, including drug delivery, tissue engineering, and wound healing. This review comprehensively explores various programmable hydrogels responsive to diverse triggers, including temperature, gene expression, color, shape, and mechanical force. The design and fabrication methods underlying these systems are detailed, highlighting the roles of crosslinkers, adhesion groups, and photosensitive functional groups. Furthermore, the key physical, chemical, and biological properties that govern the performance and functionality of hydrogels are analyzed. The review further examines the mechanisms and recent advancements in self-executing hydrogels, such as self-activated, self-oxygenated, self-expandable, and self-powered systems, demonstrating how these innovative designs drive the development of next-generation programmable hydrogels. The main challenges in hydrogel design, including complexity, reproducibility, and clinical translation, are also addressed. Finally, a perspective on future research directions, highlighting the integration of the latest technologies to realize programmable hydrogels with dynamic closed-loop responsiveness, bionic synergy, and robust clinical applicability, is offered.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/EH22_008%2F0004634" target="_blank" >EH22_008/0004634: Mechanical engineering of biological and bio-inspired systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Science
ISSN
2198-3844
e-ISSN
2198-3844
Volume of the periodical
12
Issue of the periodical within the volume
47
Country of publishing house
US - UNITED STATES
Number of pages
39
Pages from-to
nestránkováno
UT code for WoS article
001614207000001
EID of the result in the Scopus database
2-s2.0-105021498675