Enhanced frequency of micronuclei in lymphocytes from current as opposed to former uranium miners

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F11%3A43881875" target="_blank" >RIV/60076658:12110/11:43881875 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2478/v10136-011-0002-7" target="_blank" >http://dx.doi.org/10.2478/v10136-011-0002-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10136-011-0002-7" target="_blank" >10.2478/v10136-011-0002-7</a>

Result language

angličtina

Original language name

Enhanced frequency of micronuclei in lymphocytes from current as opposed to former uranium miners

Original language description

Micronuclei can be used as markers of past radiation exposure, but few studies have dealt with alpha radiation. Here we report on micronuclei in lymphocytes from uranium miners currently working at Rožná, Czech Republic, the last functioning uranium minein the European Union. A modified micronucleus-centromere test was applied, assessing the occurrence of micronuclei in stimulated lymphocytes as well as their content in terms of whole chromosomes or fragments. Compared with unexposed individuals, the miners had higher frequencies of micronucleus-containing lymphocytes and higher percentages of micronuclei without centromeres, and the differences were significant with both parameters (0.74 + 0.60 vs. 0.50 + 0.42, p=0.017 and 49 + 44 vs. 12 + 21, p=0.0002; means + standard deviations). There were also significant correlations between either of these parameters on the one hand and various dose values on the other, in particular with "retrievable" dose, i.e. a dose the effect of which sho

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

—

Project

<a href="/en/project/2B08001" target="_blank" >2B08001: Biological dosimetry of individuals occupationally exposed to alpha radiation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

151-156

UT code for WoS article

000291678000004

EID of the result in the Scopus database

—