Persistence of genetic damage in lymphocytes from former uranium miners

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F12%3A00202027" target="_blank" >RIV/68407700:21460/12:00202027 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12110/12:43884456

Result on the web

<a href="http://www.karger.com/Article/FullText/338084" target="_blank" >http://www.karger.com/Article/FullText/338084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000338084" target="_blank" >10.1159/000338084</a>

Result language

angličtina

Original language name

Persistence of genetic damage in lymphocytes from former uranium miners

Original language description

Lymphocytes from former uranium miners who finished work underground one or more decades ago were analysed with respect to possibly persisting genetic damage induced by their radiation exposure. A modified micronucleus-centromere test was used which determined the frequency of micronucleus-containing binucleate cells after cytochalasin B treatment and the percentage of centromere-free micronuclei, assessed with the help of immunofluorescence labeling of centromere protein B. Whereas the overall frequency of micronucleus-containing cells was not significantly elevated above the level found in a control group, former miners showed a greater percentage of centromere-free micronuclei, i.e. micronuclei containing only acentric fragments. Our results are inexcellent agreement with those of an earlier uranium miner study and lend support to the assumption that genetic damage from alpha radiation can persist for many years after exposure, possibly due to genomic instability. The frequency of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/2B08001" target="_blank" >2B08001: Biological dosimetry of individuals occupationally exposed to alpha radiation</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytogenetics and Genome Research

ISSN

1424-8581

e-ISSN

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Volume of the periodical

136

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

288-294

UT code for WoS article

000304993000008

EID of the result in the Scopus database

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