Determination of substitution sites in monosubstituted five-membered aromatic heterocycles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F11%3A43881934" target="_blank" >RIV/60076658:12220/11:43881934 - isvavai.cz</a>
Alternative codes found
RIV/67985858:_____/11:00357015
Result on the web
<a href="http://dx.doi.org/10.1002/mrc.2725" target="_blank" >http://dx.doi.org/10.1002/mrc.2725</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mrc.2725" target="_blank" >10.1002/mrc.2725</a>

Result language
angličtina
Original language name
Determination of substitution sites in monosubstituted five-membered aromatic heterocycles
Original language description
Similar magnitudes of proton-proton couplings across three, four, and five bonds and proton-carbon couplings across two and three bonds combined with difficult to predict substituent effects make the results of an indiscriminate use of routine (COSY, HSQC,HMBC, etc.) techniques for substitution site determination in C-monosubstituted five-membered heteroaromatics suspect. As demonstrated on two examples of natural products, the use of 1,1-ADEQUATE leads to unambiguous substitution site determination lending thus further support to suggested inclusion of 1,1-ADEQUATE data into computer-assisted structure elucidation (CASE) protocols.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
—

Project
<a href="/en/project/IAA400720706" target="_blank" >IAA400720706: Structure of silyl moieties through J(29Si-13C) couplings as determined by triple {1H, 13C}29Si NMR experiments</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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