All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Marine natural products: Bryostatins in preclinical and clinical studies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F14%3A43885594" target="_blank" >RIV/60076658:12220/14:43885594 - isvavai.cz</a>

  • Alternative codes found

    RIV/62157124:16370/14:43871807

  • Result on the web

    <a href="http://dx.doi.org/10.3109/13880209.2013.804100." target="_blank" >http://dx.doi.org/10.3109/13880209.2013.804100.</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3109/13880209.2013.804100." target="_blank" >10.3109/13880209.2013.804100.</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Marine natural products: Bryostatins in preclinical and clinical studies

  • Original language description

    Bryostatins represent an important group of pharmaceutically promising substances. These compounds are produced by commensal microorganisms naturally occurring in marine invertebrates, mainly in bryozoans. The most frequently investigated substance is bryostatin-1, which is a highly oxygenated macrolide with a polyacetate backbone. Objective: The aim of this work was to summarize documented preclinical and clinical effects of bryostatin-class compounds. Methods: A literature search was made of Medline and Web of Science databases in 2012. Results and conclusion: Our review showed that bryostatins are potent agonists of protein kinase C. In addition to this, their significant antineoplastic activity against several tumor types has also been establishedand described. Bryostatin's anticancer activity has been proved against various cancer types. Moreover, significant results have been achieved by using bryostatin-1 in combination with other therapies, including combination with vaccine t

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP503%2F12%2F0337" target="_blank" >GAP503/12/0337: Invasive bryozoan Pectinatella magnifica in the Czech Republic: its biology and secondary metabolites</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pharmaceutical Biology

  • ISSN

    1388-0209

  • e-ISSN

  • Volume of the periodical

    52

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    237-242

  • UT code for WoS article

    000329301800016

  • EID of the result in the Scopus database