Marine natural products: Bryostatins in preclinical and clinical studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F14%3A43885594" target="_blank" >RIV/60076658:12220/14:43885594 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/14:43871807
Result on the web
<a href="http://dx.doi.org/10.3109/13880209.2013.804100." target="_blank" >http://dx.doi.org/10.3109/13880209.2013.804100.</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/13880209.2013.804100." target="_blank" >10.3109/13880209.2013.804100.</a>
Alternative languages
Result language
angličtina
Original language name
Marine natural products: Bryostatins in preclinical and clinical studies
Original language description
Bryostatins represent an important group of pharmaceutically promising substances. These compounds are produced by commensal microorganisms naturally occurring in marine invertebrates, mainly in bryozoans. The most frequently investigated substance is bryostatin-1, which is a highly oxygenated macrolide with a polyacetate backbone. Objective: The aim of this work was to summarize documented preclinical and clinical effects of bryostatin-class compounds. Methods: A literature search was made of Medline and Web of Science databases in 2012. Results and conclusion: Our review showed that bryostatins are potent agonists of protein kinase C. In addition to this, their significant antineoplastic activity against several tumor types has also been establishedand described. Bryostatin's anticancer activity has been proved against various cancer types. Moreover, significant results have been achieved by using bryostatin-1 in combination with other therapies, including combination with vaccine t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP503%2F12%2F0337" target="_blank" >GAP503/12/0337: Invasive bryozoan Pectinatella magnifica in the Czech Republic: its biology and secondary metabolites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Biology
ISSN
1388-0209
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
237-242
UT code for WoS article
000329301800016
EID of the result in the Scopus database
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