Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F18%3A43898021" target="_blank" >RIV/60076658:12220/18:43898021 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00498717
Result on the web
<a href="http://dx.doi.org/10.1016/j.exppara.2018.09.001" target="_blank" >http://dx.doi.org/10.1016/j.exppara.2018.09.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.exppara.2018.09.001" target="_blank" >10.1016/j.exppara.2018.09.001</a>
Alternative languages
Result language
angličtina
Original language name
Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model
Original language description
Microsporidia are obligate intracellurar unicellular parasite of wide range of vertebrates. Although ingestion or inhalation of microsporidian spores is the main route of infection, assumed vertical transmission was described in some mammals. The present study was focused on proof of vertical transmission in mice under experimental conditions. Mice were infected with E. cuniculi genotype II intraperitoneally after mating, or perorally followed by mating in acute or chronic phase of infection. Fetuses were delivered by Caesarean section or mice were kept up to the parturition. Some of cubs were immediately after birth transferred to uninfected surrogate mothers. Group of cubs was immunosuppressed. All cubs were examined using polymerase chain reaction for the presence of Encephalitozoon after birth or in their age of 3 or 6 weeks, respectively. All fetuses delivered by Caesarean section, which were intraperitoneally or perorally infected were negative as well as all neonatal mice and youngsters tested in age of 6 weeks. Only immunosuppressed cubs and cubs of immunodeficient mice in age of 21 days were positive for Encephalitozoon cuniculi genotype II. Present results provided the evidence that transplacental transmission of Encephalitozoon cuniculi in mice occurs, but the mechanism of these transport is still unknown.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
<a href="/en/project/GA17-12871S" target="_blank" >GA17-12871S: Elucidation of different virulence and drug resistance of genotypes of Encephalitozoon cuniculi using murine model.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Parasitology
ISSN
0014-4894
e-ISSN
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Volume of the periodical
193
Issue of the periodical within the volume
říjen
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
51-57
UT code for WoS article
000447232500007
EID of the result in the Scopus database
2-s2.0-85053776958