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Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F18%3A43898021" target="_blank" >RIV/60076658:12220/18:43898021 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/18:00498717

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.exppara.2018.09.001" target="_blank" >http://dx.doi.org/10.1016/j.exppara.2018.09.001</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.exppara.2018.09.001" target="_blank" >10.1016/j.exppara.2018.09.001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Evidence of transplacental transmission of Encephalitozoon cuniculi genotype II in murine model

  • Original language description

    Microsporidia are obligate intracellurar unicellular parasite of wide range of vertebrates. Although ingestion or inhalation of microsporidian spores is the main route of infection, assumed vertical transmission was described in some mammals. The present study was focused on proof of vertical transmission in mice under experimental conditions. Mice were infected with E. cuniculi genotype II intraperitoneally after mating, or perorally followed by mating in acute or chronic phase of infection. Fetuses were delivered by Caesarean section or mice were kept up to the parturition. Some of cubs were immediately after birth transferred to uninfected surrogate mothers. Group of cubs was immunosuppressed. All cubs were examined using polymerase chain reaction for the presence of Encephalitozoon after birth or in their age of 3 or 6 weeks, respectively. All fetuses delivered by Caesarean section, which were intraperitoneally or perorally infected were negative as well as all neonatal mice and youngsters tested in age of 6 weeks. Only immunosuppressed cubs and cubs of immunodeficient mice in age of 21 days were positive for Encephalitozoon cuniculi genotype II. Present results provided the evidence that transplacental transmission of Encephalitozoon cuniculi in mice occurs, but the mechanism of these transport is still unknown.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    40301 - Veterinary science

Result continuities

  • Project

    <a href="/en/project/GA17-12871S" target="_blank" >GA17-12871S: Elucidation of different virulence and drug resistance of genotypes of Encephalitozoon cuniculi using murine model.</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Experimental Parasitology

  • ISSN

    0014-4894

  • e-ISSN

  • Volume of the periodical

    193

  • Issue of the periodical within the volume

    říjen

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    51-57

  • UT code for WoS article

    000447232500007

  • EID of the result in the Scopus database

    2-s2.0-85053776958