Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F20%3A43901278" target="_blank" >RIV/60076658:12220/20:43901278 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/20:00537265 RIV/60076658:12310/20:43901278 RIV/00064211:_____/20:W0000044
Result on the web
<a href="https://www.dovepress.com/encephalitozoon-cuniculi-genotype-ii-concentrates-in-inflammation-foci-peer-reviewed-article-JIR" target="_blank" >https://www.dovepress.com/encephalitozoon-cuniculi-genotype-ii-concentrates-in-inflammation-foci-peer-reviewed-article-JIR</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/JIR.S271628" target="_blank" >10.2147/JIR.S271628</a>
Alternative languages
Result language
angličtina
Original language name
Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci
Original language description
Background: Microsporidia of the genus Encephalitozoon are generally connected with severe infections with lethal outcome in immunodeficient hosts. In immunocompetent hosts, microsporidiosis typically establishes a balanced host-parasite relationship that produces minimal clinically overt disease. Although the alimentary tract represents one of the main primary target tissues, the mechanisms of reaching other tissues during systemic microsporidian infections remain unclear. Methods: In the present study, we tested the relation between inflammation induction in immunocompetent and immunodeficient mice and the presence of spores of E. cuniculi genotype II in selected organs and in fecal specimens by using molecular and histology methods. Results: We reported the positive connection between inflammation induction and the significant increase of E. cuniculi genotype II occurrence in inflammation foci in both immunocompetent BALB/c and immunodeficient severe combined immunodeficient (SCID) mice in the acute phase of infection and the re-activation of latent microsporidial infection following inflammation induction in immunocompetent mice. Conclusion: The results imply possible involvement of immune cells serving as vehicles transporting E. cuniculi genotype II purposefully across the whole host body towards inflammation. With increasing number of records of infections, it is necessary to reconsider microsporidia as agents responsible for various pathologies. The elucidation of possible connection with pro-inflammatory immune responses represents an important challenge with consequences for human health and development of therapeutic strategies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Inflammation Research
ISSN
1178-7031
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
2020
Country of publishing house
AU - AUSTRALIA
Number of pages
11
Pages from-to
583-593
UT code for WoS article
000575168200001
EID of the result in the Scopus database
2-s2.0-85091532713