Comparison of the Concentration of Encephalitozoon cuniculi Genotypes I and III in Inflammatory Foci Under Experimental Conditions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00557770" target="_blank" >RIV/60077344:_____/22:00557770 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/22:43904982 RIV/60076658:12220/22:43904982

Result on the web

<a href="https://www.dovepress.com/comparison-of-the-concentration-of-encephalitozoon-cuniculi-genotypes--peer-reviewed-fulltext-article-JIR" target="_blank" >https://www.dovepress.com/comparison-of-the-concentration-of-encephalitozoon-cuniculi-genotypes--peer-reviewed-fulltext-article-JIR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/JIR.S363509" target="_blank" >10.2147/JIR.S363509</a>

Result language

angličtina

Original language name

Comparison of the Concentration of Encephalitozoon cuniculi Genotypes I and III in Inflammatory Foci Under Experimental Conditions

Original language description

Background: Microsporidia of the genus Encephalitozoon are usually associated with severe infections in immunodeficient hosts while, in immunocompetent ones, microsporidiosis produces minimal clinically apparent disease. Despite their microscopic size, microsporidia are capable of causing systemic infection within a few days. However, the mechanisms by which microsporidia reach target tissues during acute infection remain unclear. Out of four genotypes of Encephalitozoon cuniculi, only three are available for experimental studies, with E. cuniculi genotype II being the best characterized. Methods: In the present study, we tested the association between inflammation induction in immunocompetent and immunodeficient mice and the presence of spores of E. cuniculi genotypes I and III in selected organs using molecular methods and compared the results with previously published data on E. cuniculi genotype II. Results: We reported the positive connection between inflammation induction and the significant increase of E. cuniculi genotypes I and III occurrence in inflammatory foci in both immunocompetent BALB/c and immunodeficient severe combined immunodeficient (SCID) mice in the acute phase of infection. The induction of inflammation resulted in increased concentration of E. cuniculi of both genotypes in the site of inflammation, as previously reported for E. cuniculi genotype II. Moreover, our study extended the spectrum of differences among E. cuniculi genotypes by the variations in dispersal rate within host bodies after experimentally induced inflammation. Conclusion: The results imply possible involvement of immune cells serving as vehicles transporting E. cuniculi towards inflammation foci. The elucidation of possible connection with pro-inflammatory immune responses represents an important challenge with implications for human health and the development of therapeutic strategies.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30303 - Infectious Diseases

Project

<a href="/en/project/GA20-10706S" target="_blank" >GA20-10706S: The Trojan Horse of the immune system: Do microsporidia exploit migrating immune cells for their own dispersal in the host body?</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Inflammation Research

ISSN

1178-7031

e-ISSN

1178-7031

Volume of the periodical

15

Issue of the periodical within the volume

APR

Country of publishing house

NZ - NEW ZEALAND

Number of pages

10

Pages from-to

2721-2730

UT code for WoS article

000797573700004

EID of the result in the Scopus database

2-s2.0-85129688416