Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F03%3A00005023" target="_blank" >RIV/60076658:12310/03:00005023 - isvavai.cz</a>

Alternative codes found

RIV/60077409:_____/03:59033014

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host

Original language description

Accelerated proliferation of the tick-borne bacterial pathogen Francisella tularensis was demonstrated in mice when the bacterium was injected together with salivary gland extract from Ixodes ricinus ticks. A significant increase in the numbers of bacteria was recorded in the dermal site of infection, the draining lymph nodes, and the spleen. Analysis of the expression of cytokine messenger ribonucleic acids showed polarization toward a Th2 profile. Salivary gland extract-mediated suppression of interleukin-12 and interferon-gamma, the cytokines required for the expression of the protective immunity against tularemic infection, apparently contributed to the decreased resistance against this tick-transmitted pathogen.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Parasitology

ISSN

0022-3395

e-ISSN

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Volume of the periodical

89

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

14-20

UT code for WoS article

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EID of the result in the Scopus database

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