The benign helminth Hymenolepis diminuta ameliorates chemically induced colitis in a rat model system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897715" target="_blank" >RIV/60076658:12310/18:43897715 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00498711
Result on the web
<a href="https://www.cambridge.org/core/journals/parasitology/article/benign-helminth-hymenolepis-diminuta-ameliorates-chemically-induced-colitis-in-a-rat-model-system/508E75BE94E58E67251B216FECC06923" target="_blank" >https://www.cambridge.org/core/journals/parasitology/article/benign-helminth-hymenolepis-diminuta-ameliorates-chemically-induced-colitis-in-a-rat-model-system/508E75BE94E58E67251B216FECC06923</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0031182018000896" target="_blank" >10.1017/S0031182018000896</a>
Alternative languages
Result language
angličtina
Original language name
The benign helminth Hymenolepis diminuta ameliorates chemically induced colitis in a rat model system
Original language description
The tapeworm Hymenolepis diminuta is a model for the impact of helminth colonization on the mammalian immune system and a candidate therapeutic agent for immune mediated inflammatory diseases (IMIDs). In mice, H. diminuta protects against models of inflammatory colitis by inducing a strong type 2 immune response that is activated to expel the immature worm. Rats are the definitive host of H. diminuta, and are colonized stably and over long time periods without harming the host. Rats mount a mild type 2 immune response to H. diminuta colonization, but this response does not generally ameliorate colitis. Here we investigate the ability of different life cycle stages of H. diminuta to protect rats against a model of colitis induced through application of the haptenizing agent dinitrobenzene sulphonic acid (DNBS) directly to the colon, and monitor rat clinical health, systemic inflammation measured by TNF alpha and IL-1 beta, and the gut microbiota. We show that immature H. diminuta induces a type 2 response as measured by increased IL-4, IL-13 and IL-10 expression, but does not protect against colitis. In contrast, rats colonized with mature H. diminuta and challenged with severe colitis (two applications of DNBS) have lower inflammation and less severe clinical symptoms. This effect is not related the initial type 2 immune response. The gut microbiota is disrupted during colitis and does not appear to play an overt role in H. diminuta-mediated protection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasitology
ISSN
0031-1820
e-ISSN
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Volume of the periodical
145
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1324-1335
UT code for WoS article
000443420600009
EID of the result in the Scopus database
2-s2.0-85048768156