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The benign helminth Hymenolepis diminuta ameliorates chemically induced colitis in a rat model system

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897715" target="_blank" >RIV/60076658:12310/18:43897715 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/18:00498711

  • Result on the web

    <a href="https://www.cambridge.org/core/journals/parasitology/article/benign-helminth-hymenolepis-diminuta-ameliorates-chemically-induced-colitis-in-a-rat-model-system/508E75BE94E58E67251B216FECC06923" target="_blank" >https://www.cambridge.org/core/journals/parasitology/article/benign-helminth-hymenolepis-diminuta-ameliorates-chemically-induced-colitis-in-a-rat-model-system/508E75BE94E58E67251B216FECC06923</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1017/S0031182018000896" target="_blank" >10.1017/S0031182018000896</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The benign helminth Hymenolepis diminuta ameliorates chemically induced colitis in a rat model system

  • Original language description

    The tapeworm Hymenolepis diminuta is a model for the impact of helminth colonization on the mammalian immune system and a candidate therapeutic agent for immune mediated inflammatory diseases (IMIDs). In mice, H. diminuta protects against models of inflammatory colitis by inducing a strong type 2 immune response that is activated to expel the immature worm. Rats are the definitive host of H. diminuta, and are colonized stably and over long time periods without harming the host. Rats mount a mild type 2 immune response to H. diminuta colonization, but this response does not generally ameliorate colitis. Here we investigate the ability of different life cycle stages of H. diminuta to protect rats against a model of colitis induced through application of the haptenizing agent dinitrobenzene sulphonic acid (DNBS) directly to the colon, and monitor rat clinical health, systemic inflammation measured by TNF alpha and IL-1 beta, and the gut microbiota. We show that immature H. diminuta induces a type 2 response as measured by increased IL-4, IL-13 and IL-10 expression, but does not protect against colitis. In contrast, rats colonized with mature H. diminuta and challenged with severe colitis (two applications of DNBS) have lower inflammation and less severe clinical symptoms. This effect is not related the initial type 2 immune response. The gut microbiota is disrupted during colitis and does not appear to play an overt role in H. diminuta-mediated protection.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10605 - Developmental biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Parasitology

  • ISSN

    0031-1820

  • e-ISSN

  • Volume of the periodical

    145

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    1324-1335

  • UT code for WoS article

    000443420600009

  • EID of the result in the Scopus database

    2-s2.0-85048768156