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Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903615" target="_blank" >RIV/60076658:12310/21:43903615 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/21:00554116 RIV/68081766:_____/21:00538427 RIV/62157124:16170/21:43879105

  • Result on the web

    <a href="https://www.mdpi.com/2076-2607/9/2/226" target="_blank" >https://www.mdpi.com/2076-2607/9/2/226</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/microorganisms9020226" target="_blank" >10.3390/microorganisms9020226</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect

  • Original language description

    Colonization by the benign tapeworm, Hymenolepis diminuta, has been associated with a reduction in intestinal inflammation and changes in bacterial microbiota. However, the role of microbiota in the tapeworm anti-inflammatory effect is not yet clear, and the aim of this study was to determine whether disruption of the microflora during worm colonization can affect the course of intestinal inflammation. We added a phase for disrupting the intestinal microbiota using antibiotics to the experimental design for which we previously demonstrated the protective effect of H. diminuta. We monitored the immunological markers, clinical parameters, bacterial microbiota, and histological changes in the colon of rats. After a combination of colonization, antibiotics, and colitis induction, we had four differently affected experimental groups. We observed a different course of the immune response in each group, but no protective effect was found. Rats treated with colonization and antibiotics showed a strong induction of the Th2 response as well as a significant change in microbial diversity. The microbial results also revealed differences in the richness and abundance of some bacterial taxa, influenced by various factors. Our data suggest that interactions between the tapeworm and bacteria may have a major impact on its protective effect.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    <a href="/en/project/LTAUSA19008" target="_blank" >LTAUSA19008: An influence of specific factors on the anti-inflammatory effect of the commensal helminth in the host gut</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Microorganisms

  • ISSN

    2076-2607

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    17

  • Pages from-to

  • UT code for WoS article

    000622807400001

  • EID of the result in the Scopus database

    2-s2.0-85099713731