The Use of Tick Salivary Proteins as Novel Therapeutics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F19%3A43899426" target="_blank" >RIV/60076658:12310/19:43899426 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/19:00518850

Result on the web

<a href="http://file:///C:/Users/jmaxerova/Downloads/fphys-10-00812.pdf" target="_blank" >http://file:///C:/Users/jmaxerova/Downloads/fphys-10-00812.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphys.2019.00812" target="_blank" >10.3389/fphys.2019.00812</a>

Result language

angličtina

Original language name

The Use of Tick Salivary Proteins as Novel Therapeutics

Original language description

The last three decades of research into tick salivary components have revealed several proteins with important pharmacological and immunological activities. Two primary interests have driven research into tick salivary secretions: the search for suitable pathogen transmission blocking or &quot;anti-tick&quot; vaccine candidates and the search for novel therapeutics derived from tick salivary components. Intensive basic research in the field of tick salivary gland transcriptomics and proteomics has identified several major protein families that play important roles in tick feeding and overcoming vertebrate anti-tick responses. Moreover, these families contain members with unrealized therapeutic potential. Here we review the major tick salivary protein families exploitable in medical applications such as immunomodulation, inhibition of hemostasis and inflammation. Moreover, we discuss the potential, opportunities, and challenges in searching for novel tick-derived drugs.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Physiology

ISSN

1664-042X

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

JUN 26 2019

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

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UT code for WoS article

000473211200004

EID of the result in the Scopus database

2-s2.0-85069797123