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Tick Salivary Compounds for Targeted Immunomodulatory Therapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901218" target="_blank" >RIV/60076658:12310/20:43901218 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/20:00537076

  • Result on the web

    <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2020.583845/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2020.583845/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fimmu.2020.583845" target="_blank" >10.3389/fimmu.2020.583845</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tick Salivary Compounds for Targeted Immunomodulatory Therapy

  • Original language description

    Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immuno-pharmacological aspects of tick salivary compounds characterizedin vitroand/orin vivoand present recent findings on non-coding RNAs that might be exploitable as immunomodulatory therapies.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Immunology

  • ISSN

    1664-3224

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    SEP 23 2020

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    15

  • Pages from-to

  • UT code for WoS article

    000575523200001

  • EID of the result in the Scopus database

    2-s2.0-85092165055