Tick Salivary Compounds for Targeted Immunomodulatory Therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901218" target="_blank" >RIV/60076658:12310/20:43901218 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/20:00537076
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2020.583845/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2020.583845/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2020.583845" target="_blank" >10.3389/fimmu.2020.583845</a>
Alternative languages
Result language
angličtina
Original language name
Tick Salivary Compounds for Targeted Immunomodulatory Therapy
Original language description
Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immuno-pharmacological aspects of tick salivary compounds characterizedin vitroand/orin vivoand present recent findings on non-coding RNAs that might be exploitable as immunomodulatory therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
SEP 23 2020
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
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UT code for WoS article
000575523200001
EID of the result in the Scopus database
2-s2.0-85092165055